protein aggregation introduction

  • Role of Protein Aggregation in Neurodegenerative Diseases

    Thus, protein aggregation is a bone to pick for biotechnology and pharmaceutical industries. The aim of this chapter is to bring a perspective to the role of misfolded proteins in neurodegenerative diseases in terms of molecular and cellular basis.

  • Protein aggregation as an antibiotic design strategy ...

    Nov 12, 2015 · In order to differentiate between the accumulation of aggregated peptide inside bacteria and intracellular peptide‐induced protein aggregation, we proceeded to carry out aggregation assays in combination with mass spectrometry in order to characterize changes in protein levels in the soluble and insoluble fraction after treatment of MRSA strain 326 with C30, C29 and Hit1 in comparison with .

  • New methods allowing the detection of protein aggregates ...

    Nov 03, 2008 · Aggregation compromises the safety and efficacy of therapeutic proteins. According to the manufacturer, the therapeutic immunoglobulin trastuzumab (Herceptin®) should be diluted in 0.9% sodium chloride before administration. Dilution in 5% dextrose solutions is prohibited.

  • An Introduction to Proteins